Junichi Koseki Selected Research

N- (3,4- dimethoxyphenethyl)- N- methyl- 3- (3- pyridyl)- 2- propenamide

12/2010	(E)-N-[(3,4-dimethoxyphenethyl)]-N-methyl-3-(3-pyridyl)-2-propenamide (TJN-331) inhibits mesangial expansion in experimental IgA nephropathy in ddY mice.
1/2010	TJN-331 improves anti-glomerular basement membrane nephritis by inhibiting the production of intraglomerular transforming growth factor-beta1.
1/2010	Effect of TJN-331 on anti-Thy1 nephritis in rats via inhibition of transforming growth factor-β1 production.

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Junichi Koseki Research Topics

Disease

4	Inflammation (Inflammations) 01/2018 - 02/2011
4	Acne Vulgaris 02/2017 - 01/2015
3	Dermatitis 02/2017 - 01/2015
3	Nephritis 02/2011 - 01/2010
2	Skin Diseases (Skin Disease) 09/2015 - 01/2015
2	Glomerulonephritis 02/2011 - 01/2010
2	IGA Glomerulonephritis (IGA Nephropathy) 12/2010 - 10/2009
2	Sclerosis 10/2009 - 12/2007
1	Infections 01/2018
1	Gastroesophageal Reflux (GERD) 01/2012
1	Dyspepsia (Indigestion) 05/2010
1	Esophagitis 05/2010
1	Proteinuria 01/2010
1	Colitis 01/2010

Drug/Important Bio-Agent (IBA)

3	jumi-haidoku-toIBA 09/2015 - 01/2015
3	N- (3,4- dimethoxyphenethyl)- N- methyl- 3- (3- pyridyl)- 2- propenamideIBA 12/2010 - 01/2010
2	Proteins (Proteins, Gene)FDA Link 02/2011 - 10/2009
2	Transforming Growth Factors (Transforming Growth Factor)IBA 02/2011 - 10/2009
2	CarbonIBA 12/2010 - 10/2009
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 01/2010 - 10/2009
1	FlavonoidsIBA 01/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2018
1	yokuininIBA 02/2017
1	peoniflorinIBA 02/2017
1	prunasinIBA 02/2017
1	keishibukuryoganIBA 02/2017
1	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2017
1	Oxygen (Dioxygen)IBA 02/2017
1	Gallic AcidIBA 02/2017
1	azelaic acid (Azelex)FDA Link 02/2017
1	AntioxidantsIBA 09/2015
1	PolyphenolsIBA 09/2015
1	Testosterone (Sustanon)FDA Link 01/2015
1	AndrogensIBA 01/2015
1	AcidsIBA 01/2012
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2011
1	RolipramIBA 02/2011
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 02/2011
1	anti-Thy antibodyIBA 02/2011
1	N- (2- (3,4- dimethoxyphenyl)- 2- oxoethyl)- N- methyl- 3- (3- pyridyl)- 2- propenamideIBA 02/2011
1	GlobulinsIBA 12/2010
1	liu-jun-zi-tangIBA 05/2010
1	antiglomerular basement membrane antibodyIBA 01/2010
1	Neutralizing AntibodiesIBA 01/2010
1	tranilastIBA 01/2010
1	SolutionsIBA 01/2010
1	Antifibrotic AgentsIBA 01/2010
1	4- (2- (N- (3- pyridylmethyl)carbamoylethenyl)phenoxy)acetateIBA 01/2010
1	Dextran SulfateIBA 01/2010
1	Drinking WaterIBA 01/2010
1	Interleukin-10 (Interleukin 10)IBA 01/2010
1	Interleukin-12 (IL 12)IBA 01/2010
1	acteosideIBA 01/2010
1	TJN-259IBA 10/2009
1	Immunoglobulin A (IgA)IBA 10/2009
1	EnzymesIBA 10/2009
1	Dihydrotachysterol (AT 10)IBA 10/2009
1	Bovine Serum AlbuminIBA 10/2009
1	ImmunosorbentsIBA 10/2009
1	Collagen Type IV (Type IV Collagen)IBA 10/2009
1	sairei-toIBA 12/2007
1	Captopril (Capoten)FDA LinkGeneric 12/2007

Therapy/Procedure

3	Oral Administration 12/2010 - 10/2009
2	Nephrectomy 12/2010 - 10/2009
1	Traditional Medicine (Folk Remedies) 01/2015
1	Intradermal Injections 01/2015
1	Therapeutics 02/2011
1	Intravenous Administration 12/2010
1	Intravenous Injections 01/2010